SRP2132

RAR, γ isoform, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• 同義詞: NR1B3, RARC
• 分類程式碼代碼: 12352202
• NACRES: NA.26

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥70% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~77 kDa
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: 800 μg/mL
• 顏色: clear colorless
• NCBI登錄號: NM_000966
• UniProt登錄號: P13631
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... RARG(5916)

描述

生化／生理作用

Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The family is defined by two domains: (a) the central, highly conserved, DNA-binding domain (DBD) of approx. 66 amino acids, and (b) the C-terminal, structurally conserved, ligand-binding domain (LBD) of approx. 250 amino acids. The amino-terminal regions are least conserved among nuclear receptor sequences. Retinoids, the natural and syntheic derivatives of vitamin A, have been shown to inhibit the growth of many human tumor cells. Although the exact mechanism for this growth suppression remains unknown, the importance of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) have been established in a number of tumor cell models. Three types of RARs have been identified (RAR, RAR, and RAR ) with homologous but slightly different retinoic acid (RA) binding domains. Transactivation assays and retinoid binding assays with RAR, RAR, and RAR have shown that each RAR has a different affinity for RA and RA analogs.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable