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Merck
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重要文件

SRP2115

Sigma-Aldrich

RNA Polymerase II, p33 subunit, GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

同義詞:

RPB3, RPB31, hRPB33, hsRPB3

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.26

生物源

human

重組細胞

expressed in E. coli

化驗

≥80% (SDS-PAGE)

形狀

frozen liquid

分子量

~59.1 kDa

包裝

pkg of 10 μg

儲存條件

avoid repeated freeze/thaw cycles

濃度

150 μg/mL

顏色

clear colorless

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... POLR2C(5432)

生化/生理作用

In human, RPB3 is encoded by the POLR2C gene. This gene encodes the third largest subunit of RNA polymerase II. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. In the pol II complex, RPB3 interacts with RPB5 and the RPB3-RPB5 interaction is intensified in the presence of three subunits, RPB7, RPB8 and RPB11. Besides, RPB3 also interacts with RPB. RPB3 is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor Myogenin. RPB3 also interact with IGFBP3.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Corbi, N., et al.
Faseb Journal, 10, 10963-10963 (2002)
J Acker et al.
The Journal of biological chemistry, 272(27), 16815-16821 (1997-07-04)
As an initial approach to characterizing the molecular structure of the human RNA polymerase II (hRPB), we systematically investigated the protein-protein contacts that the subunits of this enzyme may establish with each other. To this end, we applied a glutathione

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