SRP2057

LXR β-ligand binding domain (211-461) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• 同義詞: LXR-b, LXRB, NER, NER-I, RIP15, UNR
• 分類程式碼代碼: 12352200
• NACRES: NA.26

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥80% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~30.9 kDa
• 包裝: pkg of 10 μg
• 濃度: 700 μg/mL
• 顏色: clear colorless
• NCBI登錄號: NM_007121
• UniProt登錄號: P55055
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... NR1H2(7376)

描述

生化／生理作用

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXR β is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR α expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXR β expressed in livers of LXR α knockout mice does not compensate for the loss of LXR α. In addition, LXR β, but not LXR α, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXR β may have different biological functions.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable