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SRP0344

Sigma-Aldrich

EGFR active mouse

recombinant, expressed in baculovirus infected Sf9 cells

同義詞:

ERBB, ERRP, Wa5, epidermal growth factor receptor

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

mouse

重組細胞

expressed in baculovirus infected Sf9 cells

形狀

aqueous solution

分子量

62 kDa

包裝

pkg of 10 μg

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

mouse ... EGFR(13649)

一般說明

Mouse EGFR (GenBank Accession No. NM_207655/ NP_997538), amino acids 670-1210 with C-terminal Flag-tag, MW = 62 kDa, expressed in SF9 cells via a Baculovirus expression system.

應用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Ariel Talavera et al.
Molecular immunology, 48(12-13), 1578-1585 (2011-05-20)
The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be
Jeffrey D Kearns et al.
Molecular cancer therapeutics, 14(7), 1625-1636 (2015-04-26)
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by high-affinity EGFR ligands limits the capacity

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