SML4078

MitoBloCK-10

≥98% (HPLC)

• 同義詞: 3-​Fluoro-​benzoic acid 2-​[(5-​nitro-​2-​thienyl)​methylene]​hydrazide, 3-Fluoro-N’- [(5-nitro-2-thienyl)methylene]benzohydrazide, MB-10, Mitochondrial import blockers of the Carla Koehler laboratory-10
• 經驗公式（希爾表示法）: C₁₂H₈FN₃O₃S
• CAS號碼: 394694-98-5
• 分子量：: 293.27
• MDL號碼: MFCD00813373
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: Fc1cc(ccc1)C(=O)N\N=C\c2[s]c(cc2)[N+](=O)[O-]
• InChI: 1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+
• InChI 密鑰: QDYQZMWFIYLMNX-VGOFMYFVSA-N

描述

生化／生理作用

Mitochondrial import blocker of substances requiring inner membrane translocon TIM23.
MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears that MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable