SML4025

Drp1 inhibitor, SC9

≥98% (HPLC)

• 同義詞: N-[6-Amino-1,2,3,4-tetrahydro-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]-N-methylacetamide, SC9
• 經驗公式（希爾表示法）: C₂₁H₂₂N₈O₃S
• CAS號碼: 851471-44-8
• 分子量：: 466.52
• MDL號碼: MFCD06382355
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear (Warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: CC1=NC2=NC(SCC(N(C(C(N3)=O)=C(N)N(CC4=CC=CC=C4)C3=O)C)=O)=NN2C(C)=C1

描述

生化／生理作用

Cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1).
Drp1 inhibitor SC9 is a cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1) that binds to a switch I-adjacent grove (SWAG) on Drp1. SC9 inhibits Drp1-Fis1 interaction in cells and eases the burden of Drp1-mediated pathologies such as LPS-induced mitochondrial dysfunction. It rescues mice from LPS-induced endotoxemia.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable