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Key Documents

SML3260

Sigma-Aldrich

Stannsoporfin

≥98% (HPLC)

同義詞:

B 992, Dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-stannate(2-) (OC-6-13)-dihydrogen, SnMP, Stanate, Tin mesoporphyrin

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About This Item

經驗公式(希爾表示法):
C34H36Cl2N4O4Sn
CAS號碼:
分子量::
754.29
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

, Faint brown to dark red

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

CC1=C(CCC(O)=O)/C2=C/C3=N/C(C(C)=C3CCC(O)=O)=C\C4=C(CC)C(C)=C(/C=C5N=C(C(C)=C\5CC)/C=C1\N26)N4[Sn]6(Cl)Cl

InChI

1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;

InChI 密鑰

LLDZJTIZVZFNCM-UHEVNVKKSA-J

生化/生理作用

Stannsoporfin is a potent inhibitor of heme oxygenase 1 (HO-1) and heme oxygenase 2 (HO-2). It inhibits hepatic HO and controls serum levels of bilirubin in infants. Stannsoporfin potently inhibits myeloid HO-1 in tumors. It inhibits immune suppression of chemotherapy-elicited CD8+ T cells. Stannsoporfin concurrently administer with 5-Fluoro uracil produces immediate tumor regression in mice model of breast tumor.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Yoshiro Onoue et al.
Circulation journal : official journal of the Japanese Circulation Society, 82(11), 2905-2912 (2018-08-14)
Resistance exercise has beneficial effects for patients with peripheral arterial diseases. The hypothesis that muscle growth promotes angiogenesis by interacting with neighboring cells in ischemic lesions was assessed. Methods and Results: Skeletal muscle-specific inducible Akt1 transgenic (Akt1-TG) mice that induce growth of
Jatin Tulsulkar et al.
Brain research, 1662, 1-6 (2017-02-22)
A gender difference in stroke is observed throughout epidemiologic studies, pathophysiology, treatment and outcomes. We investigated the neuroprotective role of hemeoxygenase (HO) enzyme, which catabolizes free heme to bilirubin, carbon monoxide and biliverdin in the female brain after permanent ischemia.
Tamara Muliaditan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(7), 1617-1628 (2018-01-18)
Purpose: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immunosuppressive enzyme that is expressed in a wide variety of cancers, as a potential immune

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