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SML2422

Sigma-Aldrich

槐果碱

≥95% (HPLC)

同義詞:

(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC

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About This Item

經驗公式(希爾表示法):
C15H22N2O
CAS號碼:
分子量::
246.35
MDL號碼:
分類程式碼代碼:
12352200

生物源

Sophora alopecuroides

化驗

≥95% (HPLC)

形狀

powder

光學活性

[α]/D -26 to -35°, c = 0.5 in ethanol

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI 密鑰

NBBQEIQEBNYSFK-PUILLJIJSA-N

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生化/生理作用

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play

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