SML2392
DREADD Agonist 21 dihydrochloride
≥98% (HPLC), powder, DREADD agonist
同義詞:
11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
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About This Item
經驗公式（希爾表示法）:
C17H18N4 · 2HCl
CAS號碼:
分子量：:
351.27
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
推薦產品
product name
DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
yellow to brown
溶解度
H2O: 2 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1
生化／生理作用
Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Xin Chen et al.
ACS chemical neuroscience, 6(3), 476-484 (2015-01-15)
Over the past decade, two independent technologies have emerged and been widely adopted by the neuroscience community for remotely controlling neuronal activity: optogenetics which utilize engineered channelrhodopsin and other opsins, and chemogenetics which utilize engineered G protein-coupled receptors (Designer Receptors
Moawiah M Naffaa et al.
Cell reports, 42(7), 112783-112783 (2023-07-09)
Neurogenesis and differentiation of neural stem cells (NSCs) are controlled by cell-intrinsic molecular pathways that interact with extrinsic signaling cues. In this study, we identify a circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone (LV-SVZ). Our
Takaki Yahiro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(28), 5221-5240 (2023-06-21)
Thermoregulatory behavior in homeothermic animals is an innate behavior to defend body core temperature from environmental thermal challenges in coordination with autonomous thermoregulatory responses. In contrast to the progress in understanding the central mechanisms of autonomous thermoregulation, those of behavioral
Yoshiko Nakamura et al.
Science advances, 8(51), eadd5463-eadd5463 (2022-12-24)
The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is unknown. Using rats, here, we identify prostaglandin EP3 receptor-expressing POA neurons (POAEP3R neurons) as a pivotal bidirectional controller in the central thermoregulatory mechanism. POAEP3R neurons are activated
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