SML1908

Syrosingopine

monocarboxylate lactate transporters 1 and 4 inhibitor, powder

• 同義詞: (3β,16β,17α,18β,20α)-18-[[4-[(Ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxy-yohimban-16-carboxylic acid methyl ester, Methyl reserpate ester of syringic acid ethyl carbonate
• 經驗公式（希爾表示法）: C₃₅H₄₂N₂O₁₁
• CAS 編號: 84-36-6
• 分子量：: 666.71
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: powder

屬性

• 產品名稱: Syrosingopine,
• form: powder
• Quality Segment: 100
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• SMILES string: O=C(OC)[C@@H]1[C@]2([H])C[C@@]3([H])C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@]2([H])C[C@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H]1OC
• InChI: 1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1
• InChI key: ZCDNRPPFBQDQHR-SSYATKPKSA-N

描述

Application

Syrosingopine has been used as a monocarboxylate transporter (MCT) inhibitor

• to study its effects on anti-CD147-induced metabolon disruption in human breast cancer cells
• to study its effects on Cryptosporidium parvum-infected HCT-8 cells
• in orthogonal linear separation analysis (OLSA)-derived decomposed analysis

Biochem/physiol Actions

Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells.

Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. Syrosingopine was also found to potentiate the anticancer activity of mitochondrial electron transport chain (ETC) inhibitors. Its mechanism of action is currently unknown but may involve inhibition of glycolytic enzyme α-enolase rather than its known activity as an inhibitor of vesicular monoamine transporters VMAT1 and VMAT2.

Syrosingopine is a derivative of reserpine and inhibits monocarboxylate lactate transporters 1 and 4 (MCT1/4).

安全資訊

• 存儲類別/等級: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable