SML1729

SW044248

≥98% (HPLC)

• 同義詞: 2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
• 經驗公式（希爾表示法）: C₂₂H₂₃N₅O₂S
• CAS號碼: 522650-83-5
• 分子量：: 421.52
• MDL號碼: MFCD03487851
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329826043

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: CCC(C(NC1=C(OC)C=CC=C1)=O)SC2=NC(N(CC)C3=C4C=CC=C3)=C4N=N2

描述

生化／生理作用

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. Nos. 208925 & C9911). SW044248 is shown to exhibit antiproliferation efficacy against a subset of non-small-cell lung cancer (NSCLC) cultures (IC₅₀ <5 μM), including HCC4017 (IC₅₀ = 1.68 μM) as a result of DNA damage and apoptosis induction, while exhibiting little potency toward the non-cancerous HBEC30KT lung epithelial cells (IC₅₀ >10 μM) derived from the same patient as HCC4017.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable