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文件

SML1368

Sigma-Aldrich

CLP257

≥98% (HPLC)

同義詞:

(5Z)-5-[(4-氟代-2-羟基苯基)亚甲基]-2-(四氢-1-(2H)-哒嗪基)-4(5H)-噻唑酮

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About This Item

經驗公式(希爾表示法):
C14H14FN3O2S
CAS號碼:
分子量::
307.34
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

, white to yellow to light brown

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O

InChI

1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-

InChI 密鑰

SKCADXVKQRCWTR-GHXNOFRVSA-N

應用

CLP257已被用作人类神经元培养物中的K+- Cl- 共转运蛋白2(KCC2)增强剂。

生化/生理作用

CLP257是一种选择性的K+-Cl共转运蛋白KCC2激活剂,可恢复KCC2活性降低的神经元中受损的Cl转运。 显然,CLP257在翻译后调节血浆中的KCC2蛋白更新。
在链脲佐菌素治疗的大鼠中,通过激活精氨酸-加压素神经元中的K+- Cl- 共转运蛋白2(KCC2),CLP257介导γ-氨基丁酸(GABA)能激发。但是,它对KCC1,KCC3和KCC4无效。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Young-Beom Kim et al.
Diabetes, 67(3), 486-495 (2017-12-08)
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices
Aaron J Barbour et al.
Neurobiology of disease, 141, 104878-104878 (2020-04-29)
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption
Martin Gagnon et al.
Nature medicine, 19(11), 1524-1528 (2013-10-08)
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders have been associated with KCC2 mutations

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