推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
, white to yellow to light brown
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
InChI
1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChI 密鑰
SKCADXVKQRCWTR-GHXNOFRVSA-N
應用
CLP257已被用作人类神经元培养物中的K+- Cl- 共转运蛋白2(KCC2)增强剂。
生化/生理作用
CLP257是一种选择性的K+-Cl−共转运蛋白KCC2激活剂,可恢复KCC2活性降低的神经元中受损的Cl−转运。 显然,CLP257在翻译后调节血浆中的KCC2蛋白更新。
在链脲佐菌素治疗的大鼠中,通过激活精氨酸-加压素神经元中的K+- Cl- 共转运蛋白2(KCC2),CLP257介导γ-氨基丁酸(GABA)能激发。但是,它对KCC1,KCC3和KCC4无效。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
Diabetes, 67(3), 486-495 (2017-12-08)
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices
Neurobiology of disease, 141, 104878-104878 (2020-04-29)
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption
Nature medicine, 19(11), 1524-1528 (2013-10-08)
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders have been associated with KCC2 mutations
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