SML1258

ML099

≥98% (HPLC)

• 同義詞: 2-[(2-Phenylethyl)thio]-3-pyridinecarboxylic acid, CID-888706
• 經驗公式（希爾表示法）: C₁₄H₁₃NO₂S
• CAS號碼: 496775-95-2
• 分子量：: 259.32
• MDL號碼: MFCD00791575
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825750

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: OC(C1=CC=CN=C1SCC(C2=CC=CC=C2)=O)=O
• InChI: 1S/C14H11NO3S/c16-12(10-5-2-1-3-6-10)9-19-13-11(14(17)18)7-4-8-15-13/h1-8H,9H2,(H,17,18)
• InChI 密鑰: MJHMABNIGSEYKN-UHFFFAOYSA-N

描述

生化／生理作用

ML099 is a Ras-related GTPase activator. Mutated forms of small GTPases induce proliferation and transformation of a number of cell types as well as differentiation of neuronal cells. The only known activation mechanism of small GTPase is via guanine nucleotide-exchange factors (GEFs). Data suggests that some diseases, including immunodeficienty syndromes result from loss of function mutations in the Rac2 GTPase, and the GEF cdc42. ML099 can activate cdc42, Rac1 and Ras GTPase activity with mid to high nM EC₅₀s. GTPase activatiors could be useful tools for defining the mechanism of GEF activation of GTPases, further understanding of GTPase signaling mechanisms and study of diseases in which loss of function mutants are implicated.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable