推薦產品
product name
环孢素A，即用型溶液, 1 mg/mL in DMSO
形狀
DMSO solution
品質等級
儲存條件
protect from light
濃度
1 mg/mL in DMSO
運輸包裝
dry ice
儲存溫度
−20°C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI 密鑰
PMATZTZNYRCHOR-IMVLJIQESA-N
應用
环孢素A已用于研究其对3D近端肾小管灌注模型的毒性作用。
生化／生理作用
环孢素A(cyclosporin A)通常在移植术后给药，用于抗排斥反应。在对器官移植起效之外，环孢素A(CyA)也会带来肾毒性副作用。
环孢素A(cyclosporin A, CsA)是由多孔木霉(Tolypocladium inflatum)真菌合成的非极性环状多肽。它是一种强效的免疫抑制剂，主要作用于T淋巴细胞，已证明可在mRNA转录水平抑制多种核蛋白的T细胞活化作用。 它可与胞内受体亲环素形成复合物，复合物可结合一种钙离子/钙调依赖性蛋白磷酸酶——钙调神经磷酸酶(calcineurin)，抑制其酶活性。 CsA可抑制培养肝细胞中丙型肝炎病毒基因组的复制。 > 10 nM浓度的CsA可保护肝细胞免遭鬼笔环肽破坏。 CsA可通过抑制钙调神经磷酸酶抑制T细胞活化生产 IL2 。
有大量引用本品的文献报道，包括对于其分析特性的全面综述。
有大量引用本品的文献报道，包括对于其分析特性的全面综述。
其他說明
光敏感
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
188.6 °F - closed cup
閃點（°C）
87 °C - closed cup
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Lei Kuang et al.
Frontiers in pharmacology, 12, 770558-770558 (2021-12-18)
Background: Sepsis/septic shock is a common complication in the intensive care unit, and the opening of the mitochondrial permeability transition pore (mPTP), as well as the endoplasmic reticulum stress (ERS), play important roles in this situation. Whether the combination of
María Jiménez-Fernández et al.
Cellular and molecular life sciences : CMLS, 79(8), 468-468 (2022-08-06)
The mechanisms that control the inflammatory-immune response play a key role in tissue remodelling in cardiovascular diseases. T cell activation receptor CD69 binds to oxidized low-density lipoprotein (oxLDL), inducing the expression of anti-inflammatory NR4A nuclear receptors and modulating inflammation in
Zhenling Ma et al.
Bioscience reports, 41(1) (2021-01-05)
The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress and is implicated in the pathogenesis of lung cancer. Cyclophilin A (CypA), a member of the immunophilin family, is secreted in response to ROS. To determine
Kimberly A Homan et al.
Scientific reports, 6, 34845-34845 (2016-10-12)
Three-dimensional models of kidney tissue that recapitulate human responses are needed for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we report a bioprinting method for creating 3D human renal proximal tubules in vitro that are fully embedded
Renata Pavlič et al.
Frontiers in molecular biosciences, 8, 743403-743403 (2021-11-23)
Endometrial cancer (EC) is the most common gynecological malignancy in resource-abundant countries. The majority of EC cases are estrogen dependent but the mechanisms of estrogen biosynthesis and oxidative metabolism and estrogen action are not completely understood. Here, we evaluated formation
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務