SML0708

BMS-182874 hydrochloride

≥98% (HPLC)

• 同義詞: 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride, BMS182874, N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
• 經驗公式（希爾表示法）: C₁₇H₁₉N₃O₃S · HCl
• CAS號碼: 1215703-04-0
• 分子量：: 381.88
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• InChI: 1S/C17H19N3O3S.ClH/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4;/h5-10,19H,1-4H3;1H
• InChI 密鑰: UZZFRNZGYDOBAO-UHFFFAOYSA-N

描述

生化／生理作用

BMS-182874 is a potent selective nonpeptide endothelin ETA receptor antagonist. BMS-182874 is 1000-fold selective for ETA over ETA B receptors with a Ki of 48 nM for ETA receptors vs >50 μM for ETB.

特點和優勢

This compound is featured on the Endothelin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable