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Merck
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文件

SML0668

Sigma-Aldrich

Calhex 231 hydrochloride

≥98% (HPLC)

同義詞:

4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

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About This Item

經驗公式（希爾表示法）:
C25H27ClN2O · HCl
CAS號碼:
652973-93-8
分子量：:
443.41
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 15 mg/mL, clear

儲存溫度

−20°C

應用

Calhex 231 hydrochloride has been used:
  • as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
  • to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
  • to test its effect on acoustic response bias in zebrafish
  • in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

生化／生理作用

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Kannikar Wongdee et al.
Archives of biochemistry and biophysics, 657, 15-22 (2018-09-16)
Long-term high-calcium intake and intestinal calcium hyperabsorption are hazardous to the body. It is hypothesized that enterocytes possess mechanisms for preventing superfluous calcium absorption, including secretion of negative regulators of calcium absorption and utilization of calcium-sensing receptor (CaSR) to detect
Toshiya Minakata et al.
Frontiers in molecular neuroscience, 12, 175-175 (2019-08-06)
Maintaining Ca2+ homeostasis in lymphatic fluids is necessary for proper hearing. Despite its significance, the mechanisms that maintain the cochlear lymphatic Ca2+ concentrations within a certain range are not fully clarified. We investigated the functional expression of calcium-sensing receptor (CaSR)
Xin Zhang et al.
Mediators of inflammation, 2019, 6847087-6847087 (2019-03-25)
Increasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases. However, its role and activation mechanism during hypertension remains unclear. In this study, we tested the role and mechanism of
Roshan A Jain et al.
Current biology : CB, 28(9), 1357-1369 (2018-04-24)
Animals continuously integrate sensory information and select contextually appropriate responses. Here, we show that zebrafish larvae select a behavioral response to acoustic stimuli from a pre-existing choice repertoire in a context-dependent manner. We demonstrate that this sensorimotor choice is modulated
Pamela Mattar et al.
International journal of molecular sciences, 21(20) (2020-10-21)
Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is to understand the role of CaSR on autophagy in AT

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