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Merck
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文件

SCP0151

Sigma-Aldrich

[Leu15,Gly18]-Gastrin2-17

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About This Item

經驗公式(希爾表示法):
C95H123N19O31
分子量::
2027.10
分類程式碼代碼:
12352209
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥70%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-Gly

應用

Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells. Gastrin is found in three major forms: gastrin-34 (big gastrin); gastrin-17 (little gastrin) and gastrin-13 minigastrin.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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J F Rehfeld
Acta physiologica (Oxford, England), 201(4), 405-411 (2011-03-12)
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For
Suzana Kovac et al.
Biochimica et biophysica acta, 1813(5), 889-895 (2011-02-16)
The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years
Ana-Maria Cujba et al.
Cell reports, 38(9), 110425-110425 (2022-03-03)
The HNF1αp291fsinsC truncation is the most common mutation associated with maturity-onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the mechanism by which HNF1αp291fsinsC causes MODY3 is not fully understood. Here we use MODY3 patient and
Sara Calatayud et al.
Mini reviews in medicinal chemistry, 10(1), 8-19 (2010-04-13)
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which
Mitchell L Schubert
Current opinion in gastroenterology, 27(6), 536-542 (2011-09-08)
The review summarizes the past year's literature regarding the regulation of gastric exocrine and endocrine secretion, both basic science and clinical. Gastric acid secretion is an elaborate and dynamic process that is regulated by neural (efferent and afferent), hormonal (e.g.

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