SAB6010057

Anti-phospho-ERN1 (S724) antibody, clone 1F12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• 同義詞: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1
• 分類程式碼代碼: 12352203

屬性

• 重組細胞: expressed in HEK 293 F cells
• 品質等級: 100
• 共軛: unconjugated
• 抗體產品種類: primary antibodies
• 無性繁殖: 1F12, recombinant monoclonal
• 形狀: liquid
• 分子量: 150 kDa
• 純化經由: affinity chromatography
• 物種活性: human
• 濃度: 0.6mg/ml
• 技術: ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• 同型: IgG
• UniProt登錄號: O75460
• 運輸包裝: wet ice
• 儲存溫度: -10 to -25°C
• 目標翻譯後修改: phosphorylation (pSer724)

描述

一般說明

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

免疫原

A synthesized peptide derived from human Phospho-ERN1 (S724)

序列

GRH-pS-FSR

外觀

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

儲存和穩定性

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable