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Merck
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SAB5702988

Sigma-Aldrich

Anti-RNF20 Antibody, clone 8N4O8, Rabbit Monoclonal

同義詞:

BRE1, BRE1A, hBRE1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.46

生物源

rabbit

品質等級

材料

colorless

無性繁殖

8N4O8, monoclonal

形狀

liquid

分子量

120 kDa

物種活性

mouse, mouse

濃度

0.65 mg/mL

技術

western blot: 1:500 - 1:2000

顏色

colorless

同型

IgG

免疫原序列

MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQF

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... RNF20(56254)

一般說明

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RNF20 (Q5VTR2).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1


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