SAB5702787

Anti-Phospho-RB(pSer780) Antibody, clone 8R5F5, Rabbit Monoclonal

• 同義詞: OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb
• 分類程式碼代碼: 12352203
• NACRES: NA.46

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 8R5F5, monoclonal
• 形狀: liquid
• 分子量: 106 kDa
• 物種活性: rat, human, rat
• 濃度: 1.74 mg/mL
• 技術: immunohistochemistry: 1:50 - 1:200; western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: TLSPI
• UniProt登錄號: P06400
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... RB1(5925)

描述

一般說明

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

免疫原

A synthetic phosphorylated peptide around S780 of human RB (P06400).

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

應用

WB, IHC

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H317,H411
• 防範說明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危險分類: Aquatic Chronic 2 - Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3