SAB5702250

Anti-CLDN18.2 Antibody, clone 3J4G7, Rabbit Monoclonal

• 同義詞: CLDN18,SFTA5,SFTPJ
• 分類程式碼代碼: 12352203
• NACRES: NA.46

屬性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 3J4G7, monoclonal
• 形狀: liquid
• 物種活性: human
• 濃度: 1.191 mg/mL
• 技術: immunohistochemistry: 1:50 - 1:200
• 顏色: colorless
• 同型: IgG
• UniProt登錄號: P56856
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CLDN18.2(51208)

描述

一般說明

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

免疫原

A synthetic peptide of human CLDN18.2.

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

應用

IHC

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H317,H411
• 防範說明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危險分類: Aquatic Chronic 2 - Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3