SAB4700323

Monoclonal Anti-HLA-G , (C-terminal) antibody produced in mouse

clone 5A6G7, purified immunoglobulin, buffered aqueous solution

• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 5A6G7, monoclonal
• 形狀: buffered aqueous solution
• 物種活性: human
• 濃度: 1 mg/mL
• 技術: flow cytometry: suitable
• 同型: IgG1
• NCBI登錄號: NM_002127.5
• UniProt登錄號: P17693
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... HLA-G(3135)

描述

一般說明

Human histocompatibility leukocyte antigen–G (HLA-G) belongs to the non-classical class I HLA family. It is encoded by the gene mapped to human chromosome 6p21. Unlike other members of the human class I gene family, HLA-G is expressed specifically in extraembryonic tissues during gestation.

The antibody 5A6G7 allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.

免疫原

C-terminal amino acid sequence (22-mer) of soluble HLA-G5 and HLA-G6 proteins coupled to ovalbumin

應用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化／生理作用

Human histocompatibility leukocyte antigen-G (HLA-G) molecule facilitates the regulation of maternal tolerance to the fetus by interacting with inhibitory receptors on natural killer (NK) cells. The encoded protein is involved in the embryonic development and/or the fetal-maternal immune response. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable