生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 69 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr292)
基因資訊
human ... ZAP70(7535)
一般說明
Zeta-chain-associated protein kinase 70 (ZAP70) is a tyrosine kinase, present in T cells and natural killer (NK) cells. It belongs to the spleen tyrosine kinase (Syk) family. This gene is mapped to human chromosome 2q11.
免疫原
The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr292.
Immunogen Range: 258-307
Immunogen Range: 258-307
生化／生理作用
Zeta-chain-associated protein kinase 70 (ZAP70) plays an important role in T cell receptor (TCR) signaling. It acts as an adaptor protein to increase BCR (B-cell receptor) signaling. This protein is required for T-cell transendothelial migration mediated by C-X-C motif chemokine ligand 12.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
Shah NH, et al.
eLife, 5, e20105-e20105 (2016)
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Li K, et al.
Annals of Biomedical Engineering, 44(12), 3510-3521 (2016)
The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system
Alsadeq A, et al.
Haematologica, 102(2), 346-355 (2017)
Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype
Paloneva J, et al.
American Journal of Human Genetics, 71(3), 656-662 (2002)
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