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SAB4502745

Sigma-Aldrich

Anti-SFRP2 antibody produced in rabbit

affinity isolated antibody

同義詞:

FRP-2, Frizzled-related protein 2, SARP-1, Secreted apoptosis-related protein 1, sFRP-2

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 33 kDa

物種活性

rat, mouse, human

濃度

~1 mg/mL

技術

ELISA: 1:5000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SFRP2(6423)

一般說明

Anti-SFRP2 Antibody detects endogenous levels of total SFRP2 protein.
The SFRP2 (secreted frizzled related protein 2) gene is mapped to human chromosome 4q31.3. It is found to be expressed in sclerotome.

免疫原

The antiserum was produced against synthesized peptide derived from human SFRP2.

Immunogen Range: 119-168

生化/生理作用

SFRP2 (secreted frizzled related protein 2) promotes phosphorylation and retards the expression of nuclear β-catenin and inhibits the canonical Wnt signaling pathway. SFRP2 is known to enhance osteogenic differentiation in mesenchymal stem cells.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway.
Jin L
Cellular & Molecular Biology Letters, 22:14, 1-14 (2017)
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
Lee CS
Development, 127(1), 109-118 (2000)
A novel susceptibility locus for Hirschsprung's disease maps to 4q31.3-q32.3.
Brooks AS
Journal of medical Genetics, 43(7), 1-6 (2006)

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