生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 86 kDa
物種活性
mouse, rat, human
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IKBKB(3551)
一般說明
IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.
免疫原
The antiserum was produced against synthesized peptide derived from human IKK-beta.
Immunogen Range: 166-215
Immunogen Range: 166-215
應用
Anti-IKK-β antibody produced in rabbit has been used in western blotting.
生化／生理作用
Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-KB ligand-induced nuclear factor-KB activation in glucocorticoid-induced osteoporosis.
Liu Y, et al.
Experimental and Therapeutic Medicine, 14(5), 4009-4016 (2017)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Michael A. R, et al.
Genes & Development, 30(16), 1837- 1851 (2016)
Canonical nuclear factor KB pathway links tumorigenesis of synchronous mantle-cell lymphoma, clear-cell renal-cell carcinoma, and GI stromal tumor.
Guo R, et al.
Journal of Clinical Oncology, 29(10), e257-e261 (2011)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
Yuanxin Liu et al.
Experimental and therapeutic medicine, 14(5), 4009-4016 (2017-10-27)
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield
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