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SAB4500043

Sigma-Aldrich

Anti-G3BP-1 antibody produced in rabbit

affinity isolated antibody

同義詞:

ATP-dependent DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, HDH-VIII, Ras GTPase-activating protein-binding protein 1

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 52 kDa

物種活性

mouse, human

濃度

~1 mg/mL

技術

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... G3BP1(10146)

一般說明

Anti-G3BP-1 Antibody detects endogenous levels of total G3BP-1 protein.
G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) is a constituent of SGs (stress granules). It is located on human chromosome 5q14.2-5q33.3.

免疫原

The antiserum was produced against synthesized peptide derived from human G3BP-1.

Immunogen Range: 199-248

生化/生理作用

G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) blocks the replication of HIV-1 (human immunodeficiency virus) in macrophages and T-cells. In gastric cancer patients, overexpression of G3BP1 leads to imperfect clinical predictions. It is required for the interactions of SG–PB (stress granule-processing bodies).

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Novel Role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in Adhesion and Migration of 32D Myeloid Progenitor Cells
Schwarz K, et al.
The Open Hematology Journal, 6 (2012)
Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients
Min L, et al.
Histopathology, 67(5), 677-688 (2015)
G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA
Jimenez VC, et al.
Virology, 486, 94-104 (2015)
G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.
Aulas A, et al.
The Journal of Cell Biology, 209(1), 73-84 (2015)
Hideaki Matsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(2), 135-146 (2013-01-03)
Upon exposure to various environmental stresses such as arsenite, hypoxia, and heat shock, cells inhibit their translation and apoptosis and then repair stress-induced alterations, such as DNA damage and the accumulation of misfolded proteins. These types of stresses induce the

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