SAB4300663

抗 PKM1 兔抗

affinity isolated antibody

• 同義詞: Anti-OIP3, Anti-PK2, Anti-PK3, Anti-PKM
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~60 kDa
• 物種活性: mouse, human
• 濃度: 1 mg/mL
• 技術: western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (V-R-A-S-S)
• NCBI登錄號: NM_182470.1
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PKM1(5315)

描述

一般說明

PKM1 (pyruvate kinase M1/2) is an enzyme that belongs to the pyruvate kinase (PK) family. It is upregulated in majority of the cells other than adult muscle, brain and liver. PKM has two isoforms, M1 and M2, encoded by gene located on chromosome 15q23. PKM1 can exist as a tetramer whereas PKM2 can remain as dimer and tetramer.

The antibody detects endogenous levels of total PKM1 protein.

免疫原

Peptide sequence around aa. 399-403 (V-R-A-S-S), according to the protein NP_872270.1

生化／生理作用

Pyruvate kinase (PK) is an important enzyme in glycolysis as it helps to convert phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase-M2 (PKM2) knockdown prevents the multiplication, movement and invasion in ovarian cancer SKOV3 and OVCAR3 cells. It plays an important role in cell survival to oxidative stress. It also participates in the development of tumor.

特點和優勢

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標靶描述

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable