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SAB4300419

Sigma-Aldrich

Anti-CDKN1A (Ab-145) antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-CAP20 antibody produced in rabbit, Anti-CDKN1 antibody produced in rabbit, Anti-CIP1 antibody produced in rabbit, Anti-MDA-6 antibody produced in rabbit, Anti-cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody produced in rabbit

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

~21 kDa

物種活性

human

濃度

1 mg/mL

技術

western blot: 1:500-1:1000

同型

IgG

免疫原序列

(R-Q-T-S-M)

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CDKN1A(1026)

免疫原

Peptide sequence around aa. 143-147 (R-Q-T-S-M), according to the protein CDKN1A.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Xiaojun Shu et al.
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Xiang Li et al.
Oxidative medicine and cellular longevity, 2019, 9706792-9706792 (2019-03-27)
Multiple signaling pathways including ERK, PI3K-Akt, and NF-κB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2 provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes

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