SAB4200380

Anti-LAYN antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 同義詞: Anti-LAYN antibody produced in rabbit, Anti-Layilin
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~43 kDa
• 物種活性: human
• 濃度: ~1.0 mg/mL
• 技術: indirect immunofluorescence: 2.5-5.0 μg/mL using human A549 cells.; western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human LAYN.
• UniProt登錄號: Q6UX15
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... LAYN(143903)

描述

一般說明

Layilin (LAYN) is a cell surface hyaluronan receptor, originally identified as a binding partner of talin located in membrane ruffles of spreading cells. LAYN is widely expressed in different cell lines and tissues. This gene is mapped to human chromosome 11q.

免疫原

synthetic peptide corresponding to an internal region of human LAYN, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

應用

Anti-LAYN antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化／生理作用

Layilin (LAYN) binds to hyaluronan, a ubiquitous extracellular matrix component involved in the invasion of a variety of tumour cells, through its extracellular domain and to cytoskeleton-membrane linker proteins including Merlin and Radixin, through its cytoplasmic domain, implicating LAYN in cell adhesion and motility. LAYN is overexpressed in the human lung carcinoma A549. LAYN down-regulation by RNA interference, inhibits invasion and lymphatic metastasis of A549 cells.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable