SAB4200263

Anti-PLEKHA7 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 同義詞: Anti-Pleckstrin homology domain-containing family A member 7
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~130 kDa
• 物種活性: human
• 濃度: ~1.0 mg/mL
• 技術: immunoprecipitation (IP): 2.5-5 μg using lysates of HEK- 293T cells overexpressing human PLEKHA7; indirect immunofluorescence: 1.0-2.0 μg/mL using Caco2 cells; western blot: 0.5-1 μg/mL using lysates of HEK- 293T cells overexpressing human PLEKHA7
• UniProt登錄號: Q6IQ23
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PLEKHA7(144100)

描述

一般說明

The Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) gene is located on the human chromosome 11p15.2-p15.1. The encoded protein is compsed of WW, pleckstrin homology (PH) and coiled-coil (CC) domains. It is a part of cadherin-based protein complex in mammalian epithelial cells.

特異性

Anti-PLEKHA7 (N-terminal) recognizes human PLEKHA7.

免疫原

synthetic peptide corresponding to the N- terminal region of human PLEKHA7, conjugated to KLH. The corresponding sequence differs by two amino acids in mouse.

應用

Anti-PLEKHA7 (N-terminal) antibody produced in rabbit is suitable for:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生化／生理作用

Pleckstrin homology domain-containing family A, member 7 (PLEKHA7) protein is involved in the cadherin-based protein complex mediated anchoring of microtubule minus ends to the zonula adherens (ZA). This process is neccessary for the biogenesis of specialized junction. PLEKHA7 forms complexes with E-cadherin and cadherin associated protein p120-catenin complexes. It significantly aids in the translocation of NEZHA to the ZA.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

儲存和穩定性

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable