SAB4200242

Anti-MAN1C1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 同義詞: Anti-1,2-alpha-mannosidase IC, mannosyl-oligosaccharide 1,2-alpha-mannosidase IC, Anti-HMIC, Anti-MAN1A3, Anti-MAN1C, Anti-mannosidase, alpha, class 1C, member 1, Anti-pp6318, Anti-processing alpha-1,2-mannosidase IC
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~71 kDa
• 物種活性: rat, human
• 濃度: ~1.0 mg/mL
• 技術: western blot: 1-0.2 μg/mL using whole extracts of HEK-293 cells overexpressing human MAN1C1; western blot: 5-10 μg/mL using whole extracts of rat liver
• UniProt登錄號: Q9NR34
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MAN1C1(57134) ; rat ... Man1c1(362625)

描述

一般說明

Mannosidase alpha class 1C member 1 (MAN1C1) is a member of the glycosyl hydrolase 47 family. MAN1C1 is a type II membrane protein with sequence similarity to class Iα,2-mannosidases, which localizes to the Golgi apparatus membrane.

應用

Anti-MAN1C1 antibody produced in rabbit has been used in immunoblotting.

生化／生理作用

Mannosidase alpha class 1C member 1 (MAN1C1) is involved in the maturation of Asn-linked oligosaccharides and quality control. It trims α-1,2-linked mannose residues from Glc₃Man₉GlcNA_c2 to produce the Man₅GlcNA_c2 processing intermediate. MAN1C1 overexpression accelerates endoplasmic reticulum-associated protein degradation (ERAD) of terminally misfolded human null Hong Kongα1-antitrypsin.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable