推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~195 kDa
物種活性
mouse, human
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed NIH-3T3 cells
western blot: 2-4 μg/mL using nuclear extract of HEK-293T
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XRN1(54464)
mouse ... Xrn1(24127)
rat ... Xrn1(300944)
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一般說明
5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.
應用
Anti-XRN1 antibody produced in rabbit has been used in:
- immunostaining
- immunoblotting
- immunofluorescence.
生化／生理作用
5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Alternative RISC assembly: Binding and repression of microRNA-mRNA duplexes by human Ago proteins
Janas MM, et al.
RNA, 18(11), 2041-2055 (2012)
XRN 5'?3' exoribonucleases: structure, mechanisms and functions.
Nagarajan VK
Biochimica et Biophysica Acta, 1829, 590-603 (2013)
Nainita Roy et al.
Skeletal muscle, 11(1), 18-18 (2021-07-10)
During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that promote a poised or primed state, including altered RNA turnover and translational repression. Here
Maja M Janas et al.
RNA (New York, N.Y.), 18(11), 2041-2055 (2012-09-29)
MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate protein output from the majority of human mRNAs. In contrast to the consensus view that all miRNAs are associated with Argonaute (Ago) proteins, we determine that miRNAs are expressed in a
Degradation of initiator tRNAMet by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells.
Watanabe K
Nucleic Acids Research, 41, 4671-4685 (2013)
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