SAB4200024

Anti-Notch 1 antibody, Rat monoclonal

clone ICN 5B5, purified from hybridoma cell culture

• 同義詞: Anti-Notch homolog 1, translocation-associated (Drosophila), Anti-TAN1, hN1, neurogenic locus notch homolog protein 1, Anti-Translocation-associated notch protein, Monoclonal Anti-Notch 1 antibody produced in rat
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rat
• 共軛: unconjugated
• 抗體表格: purified from hybridoma cell culture
• 抗體產品種類: primary antibodies
• 無性繁殖: ICN 5B5, monoclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~120 kDa
• 物種活性: human
• 包裝: antibody small pack of 25 μL
• 濃度: ~1.0 mg/mL
• 技術: western blot: 2-4 μg/mL using whole extract of human Jurkat cells and developing with a sensitive film
• 同型: IgG2b
• UniProt登錄號: P46531
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NOTCH1(4851)

描述

一般說明

Monoclonal Anti-Notch 1 (rat IgG2b isotype) is derived from the hybridoma ICN 5B5 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant fusion protein corresponding to a fragment of human Notch 1 fusion protein. Notch receptor 1 (Notch1) gene is located on human chromosome 9q34.

應用

Monoclonal Anti-Notch 1 antibody produced in rat has been used in immunoblotting.

生化／生理作用

In chronic obstructive pulmonary disease, notch receptor 1 (Notch1) helps to modulate endothelial apoptosis via the extracellular signal-regulated kinase (ERK) pathway. Overexpression of Notch1 helps to guard endothelial cell from apoptosis. Knockdown of Notch1 results in the enhancement of apoptotic cells. Notch1 serves as a tumor suppressor gene in mammalian epidermis and is a determinant of keratinocyte differentiation. Notch signaling is believed to participate in several human neoplasms including T-cell acute lymphoblastic leukemia.

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable