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Merck
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重要文件

SAB4100599

Sigma-Aldrich

Anti-KRAS Antibody

mouse monoclonal, KRAS-A582

同義詞:

Anti-C-K-RAS, Anti-K-RAS2A, Anti-K-RAS2B, Anti-K-RAS4A, Anti-K-RAS4B

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

產品名稱

Anti-KRAS antibody, Mouse monoclonal, clone KRAS-A582, purified from hybridoma cell culture

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified from hybridoma cell culture

抗體產品種類

primary antibodies

無性繁殖

KRAS-A582, monoclonal

形狀

aqueous solution

分子量

antigen predicted mol wt 27.9 kDa

物種活性

human

技術

western blot: suitable using 5-10ug/ml using HEK-293 cells expressing KRAS

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... KRAS(3845)

一般說明

The kirsten rat sarcoma-2 virus oncogene (KRAS) gene is mapped to human chromosome 12p12.1 and belongs to the family of Ras genes. The protein encoded is a small guanosine nucleotide-bound GTPases belonging.

免疫原

KRAS purified recombinant protein

生化/生理作用

Mutation in the KRAS gene causes non small-cell lung cancer and promotes tumor initiation, progression and metastasis. Altered KRAS gene also offers resistance to chemotherapy. It is involved in the signal transduction between epidermal growth factor receptor (EGFR) to the nucleus.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

RAS-expanded mutations and HER2 expression in metastatic colorectal cancer: a new step of precision medicine
Valentini AM, et al.
Applied Immunohistochemistry & Molecular Morphology, 26(8), 539-539 (2018)
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
Jin H, et al.
Journal of Experimental & Clinical Cancer Research, 38(1), 165-165 (2019)
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
Tidyman WE and Rauen KA
Current Opinion in Genetics & Development, 19(3), 230-236 (2009)

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