SAB3500027

Anti-ZBED1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-ALTE, Anti-DREF, Anti-TRAMP, Anti-Zinc finger BED-type domain containing 1, Anti-hDREF
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 物種活性: human, mouse
• 技術: indirect ELISA: suitable; western blot: suitable
• NCBI登錄號: AAH15030
• UniProt登錄號: O96006
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... ZBED1(9189)

描述

免疫原

ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.

特點和優勢

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標靶描述

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500027.

外觀

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable