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SAB2900401

Sigma-Aldrich

Anti-XAF1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

XAF 1, XAF-1, XAF1, XIAP associated factor-1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

mouse, human

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... XAF1(54739)

一般說明

XIAP associated factor 1 (XAF1) is a cytokine-regulated protein expressed in the cytoplasm. It contains a tumor necrosis factor receptor-associated factor (TRAF) domain. The gene encoding XAF1 is localized on human chromosome 17p13.1.

免疫原

Synthetic peptide from human XAF1/XIAP-assoicated factor 1

應用

Anti-XAF1 antibody produced in rabbit has been used in Western blotting.

生化/生理作用

XIAP associated factor 1 (XAF1) is an inhibitor of tumor growth. It has a role in restoring X-linked inhibitor of apoptosis (XIAP)-suppressed caspase activity.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability.
Lin B
Febs Letters (2016)
[XAF1 inhibits cell proliferation and induces apoptosis in human lung adenocarcinoma cell line A549 in vitro].
Chen D
Zhongguo Fei ai za Zhi = Chinese Journal of Lung Cancer (2014)
XAF1 is frequently methylated in human esophageal cancer.
World Journal of Gastroenterology (2012)
Andrea Lunardi et al.
Nature genetics, 45(7), 747-755 (2013-06-04)
Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
Andrea Lunardi
Nature Genetics (2013)

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