SAB2702004

Anti-PPP1CB antibody produced in rabbit

• 同義詞: PP-1B, PP1B, PP1beta, PPP1CD
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: liquid
• 分子量: 37 kDa
• 物種活性: human, mouse
• 濃度: 0.5 mg/mL
• 技術: immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 500-3000
• UniProt登錄號: P62140
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... PPP1CB(5500)

描述

一般說明

Protein phosphatase 1 catalytic subunit β (PPP1CB) gene is mapped to human chromosome 2p23.2. It is expressed in spines, dendrites, axon terminals, axons and glia in the prefrontal cortex. PPP1CB is expressed at higher levels in dendrites. It has a calcineurin-like phosphoesterase domain, a metallophosphatase domain and a serine/threonine protein phosphatase domain.

免疫原

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 274 of PPP1CB

應用

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生化／生理作用

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
In the brain, protein phosphatase 1 catalytic subunit β (PPP1CB) regulates synaptic plasticity. Mutation in the gene causes intellectual disability (ID), congenital heart disease.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317,H412
• 防範說明: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• 危險分類: Aquatic Chronic 3 - Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable