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重要文件

SAB1306806

Sigma-Aldrich

ANTI-MSL1 (CENTER) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

MSL1, MSL1L1, Male-specific lethal 1 homolog, Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

67128 Da

物種活性

human

技術

western blot: 1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... MSL1(339287)

一般說明

The gene MSL1 (male specific lethal 1 homolog) encodes a histone acetyl transferase-associated protein that spans a length of 614 amino acid residues. It does not contain any globular domains.

生化/生理作用

The gene MSL1 (male specific lethal 1 homolog) encodes a protein associated with mammalian MOF (male-absent-on-the-first)-MSL (male-specific-lethal) complex that is also referred to as the ‘dosage compensation complex′ (DCC). This complex is involved in the equalization of X-chromosomal genes expression between males and females. It is found to form a complex with Nupr1 (nuclear protein 1) in the nucleus in response to DNA-damage and may be involved in DNA repair activity. MSL1 protein is found to regulate acetylation of global histone H4 via its interaction with KAT8 (lysine acetyltransferase 8).

外觀

Supplied in PBS with 0.09% (W/V) sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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David Aguado-Llera et al.
PloS one, 8(10), e78101-e78101 (2013-11-10)
The stress protein Nupr1 is a highly basic, multifunctional, intrinsically disordered protein (IDP). MSL1 is a histone acetyl transferase-associated protein, known to intervene in the dosage compensation complex (DCC). In this work, we show that both Nupr1 and MSL1 proteins
Ruslan I Dmitriev et al.
Journal of cellular biochemistry, 115(11), 1967-1973 (2014-06-11)
MSL1 protein regulates global histone H4 acetylation at residue K16 in stem and cancer cells, through interaction with KAT8. The functional significance of mammalian MSL1 isoforms, involved in various protein interactions, is poorly understood. We report the identification of a

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