SAB1300002

Monoclonal Anti-SUV39H1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• 同義詞: Anti-KMT1A, Histone-lysine N-methyltransferase, H3 lysine-9 specific 1, Suppressor of variegation 3-9 homolog 1,
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: mouse
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 42AT239.96.72, monoclonal
• 形狀: buffered aqueous solution
• 物種活性: human, mouse
• 技術: indirect ELISA: 1:1000; western blot: 1:100-1:500
• 同型: IgG1
• NCBI登錄號: NP_003164
• UniProt登錄號: O43463
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... SUV39H1(6839)

描述

一般說明

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

免疫原

SUV39H1 (XM_047059, N Terminal)
This antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.

外觀

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable