S8939

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

• MDL號碼: MFCD03458482
• 分類程式碼代碼: 51111800
• NACRES: NA.32

屬性

• 重組細胞: expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
• 品質等級: 200
• 形狀: buffered aqueous solution
• 分子量: ~48 kDa by SDS-PAGE
• UniProt登錄號: O00141
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... SGK1(6446)

描述

一般說明

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

生化／生理作用

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

Kinase assays.

單位定義

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

外觀

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

法律資訊

Brij is a registered trademark of Croda International PLC

安全資訊

• 儲存類別代碼: 10 - Combustible liquids