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Merck
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文件

S6626

Sigma-Aldrich

毒毛旋花子苷元

同義詞:

3β,5,14-三羟基-19-氧-5β,20(22)-强心苷, ;毒毛旋花苷配基, K-毒毛旋花子甙元, 毒毛旋花子甙元, 毒毛旋花子苷K, 毒毛旋花子苷元, 毒毛旋花甙元, 羊角拗定, 羊角拗甾醇

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About This Item

經驗公式(希爾表示法):
C23H32O6
CAS號碼:
分子量::
404.50
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

儲存溫度

−20°C

SMILES 字串

C[C@@]12[C@@](CC[C@@H]2C(CO3)=CC3=O)(O)[C@]4([H])CC[C@]5(O)C[C@@H](O)CC[C@]5(C([H])=O)[C@@]4([H])CC1

InChI

1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3

InChI 密鑰

ODJLBQGVINUMMR-UHFFFAOYSA-N

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應用

毒毛旋花子甙元可用于合成乙酰毒毛旋花子甙元,已研究其对狗隐静脉神经递质释放的影响。3

生化/生理作用

毒毛旋花子甙元(Strophanthidin)是一种强心苷,可提高心肌细胞中的Na+/K+-ATP酶活性。1在兔肾皮质切片中,它可降低钾含量,提高钠含量。2

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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Niaz Ahmad et al.
Kidney international, 66(1), 77-90 (2004-06-18)
Tissue damage at the time of organ transplantation has a negative impact on the subsequent success of the procedure, both in the immediate and longer term. Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically
Julio Altamirano et al.
The Journal of physiology, 575(Pt 3), 845-854 (2006-07-11)
Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na(+)-K(+)-ATPase inhibition, causing increased intracellular [Na(+)] and consequent Ca(2+) gain via the Na(+)-Ca(2+) exchanger (NCX). However, recent studies suggested alternative mechanisms of glycoside-induced inotropy: (1) direct activation of sarcoplasmic reticulum Ca(2+)
L W Woods et al.
Veterinary pathology, 41(3), 215-220 (2004-05-11)
Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding
Yi-Chi Wang et al.
Journal of neurophysiology, 96(1), 109-118 (2006-02-10)
Cell-attached and whole cell recording techniques were used to study the effects of electrogenic sodium pump on the excitability of rat suprachiasmatic nucleus (SCN) neurons. Blocking the sodium pump with the cardiac steroid strophanthidin or zero K+ increased the spontaneous
Sara Arganda et al.
Nature neuroscience, 10(11), 1467-1473 (2007-10-02)
Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen in many neuronal types is also involved in neuronal coding. We took intracellular

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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