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S1875

Sigma-Aldrich

(-)-东莨菪碱 氢溴酸盐 三水合物

≥98% (HPLC), powder

同義詞:

天仙子碱 氢溴酸盐, 莨菪胺

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About This Item

經驗公式（希爾表示法）:
C17H21NO4 · HBr · 3H2O
CAS號碼:
6533-68-2
分子量：:
438.31
Beilstein:
6100669
MDL號碼:
MFCD00150066
分類程式碼代碼:
12352116
PubChem物質ID:
24277871
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]25/D −24 to −26°, c = 5 in H2O(lit.)

顏色

white to off-white

mp

195-199 °C (dry matter) (lit.)

溶解度

H2O: 50 mg/mL

SMILES 字串

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1

InChI 密鑰

LACQPOBCQQPVIT-SEYKEWMNSA-N

基因資訊

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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生化／生理作用

竞争性非选择性毒蕈碱型乙酰胆碱拮抗剂。东莨菪碱所致的实验室动物记忆障碍是常用的记忆缺陷模型。

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300 + H310 + H330

危險分類

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析證明 (COA)

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Víctor Manuel Torres-García et al.
Psychopharmacology (2024-06-01)
Muscarinic receptor activity in the basolateral amygdala (BLA) is known to be involved in plasticity mechanisms that underlie emotional learning. The BLA is involved in the Attenuation of Neophobia, an incidental taste learning task in which a novel taste becomes
Min-Hee Pang et al.
Neurobiology of learning and memory, 94(2), 206-213 (2010-08-06)
Although cholinergic mechanisms have been widely implicated in learning and memory processes, few studies have investigated the specific contribution of hippocampal cholinergic transmission during trace fear conditioning, a form of associative learning involving a temporal gap between two stimuli. Microinfusions
Sitthisak Thongrong et al.
Biomedical reports, 21(3), 130-130 (2024-07-29)
Pinostrobin, a key bioactive compound found in the medicinal plant Boesenbergia rotunda (L.), has been noted for its beneficial biological properties including antioxidant, anti-inflammation, anti-cancer and anti-amnesia activities. In view of this, the present study purposed to evaluate the neuroprotective
Silviya Abarova et al.
Biochimica et biophysica acta, 1863(11), 2934-2941 (2017-08-06)
Differential scanning calorimetry was applied to evaluate the efficacy of preventive treatments with biologically active compounds of plant origin against neurodegenerative disorder in mice. As we reported recently, large differences exist between the heat capacity profiles of water-soluble brain proteome
David Reiss et al.
Psychopharmacology, 231(22), 4337-4347 (2014-04-29)
Recognition memory is an important aspect of human declarative memory and is one of the routine memory abilities altered in patients with amnestic syndrome and Alzheimer's disease. In rodents, recognition memory has been most widely assessed using the novel object
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