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S0826

Sigma-Aldrich

S-PMH

≥98% (HPLC)

同義詞:

(Z)-5-(4-(ethylthio)benzylidene)-hydantoin, (Z)-5-[4-(Ethylthio)benzylidene]imidazolidine-2,4-dione, 5-(4-Ethylsulfanylbenzylidene)imidazolidine-2,4-dione

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About This Item

經驗公式(希爾表示法):
C12H12N2O2S
CAS號碼:
分子量::
248.30
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: >20 mg/mL

儲存溫度

2-8°C

SMILES 字串

CCSc1ccc(cc1)\C=C2/NC(=O)NC2=O

InChI

1S/C12H12N2O2S/c1-2-17-9-5-3-8(4-6-9)7-10-11(15)14-12(16)13-10/h3-7H,2H2,1H3,(H2,13,14,15,16)/b10-7-

InChI 密鑰

UWMDBDYLNJITCD-YFHOEESVSA-N

生化/生理作用

S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.

特點和優勢

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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