R4282

RF9 trifluoroacetate salt

≥97% (HPLC)

• 同義詞: 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
• 經驗公式（希爾表示法）: C₂₆H₃₈N₆O₃ · xC₂HF₃O₂
• CAS號碼: 876310-60-0
• 分子量：: 482.62 (free base basis)
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824030
• NACRES: NA.77

屬性

• 化驗: ≥97% (HPLC)
• 溶解度: H₂O: 20 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1
• InChI 密鑰: GPVFYPYIOXHDCU-CFIUKZCSSA-N

描述

生化／生理作用

RF9 is a neuropeptide FF receptor antagonist.

RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)