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R123

Sigma-Aldrich

RBI 257 maleate salt

solid

同義詞:

1-[4-Iodobenzyl]-4-[[2-[3-isopropoxy]pyridyl]-methylamino]piperidine maleate salt, p-Iodo-U-101,958 maleate salt

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About This Item

經驗公式(希爾表示法):
C21H28IN3O · C4H4O4
分子量::
581.44
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

形狀

solid

顏色

white

溶解度

H2O: 0.2 mg/mL
ethanol: 1 mg/mL
0.1 M HCl: 7 mg/mL
DMSO: 9 mg/mL

儲存溫度

2-8°C

SMILES 字串

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)Oc1cccnc1N(C)C2CCN(CC2)Cc3ccc(I)cc3

生化/生理作用

High affinity D4 dopamine receptor ligand.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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N S Kula et al.
European journal of pharmacology, 331(2-3), 333-336 (1997-07-23)
RBI-257 (1-[4-iodobenzyl]-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperid ine), the p-iodobenzyl analog of U-101,958 (1-benzyl-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperidine) had a lower dissociation constant (Ki = 0.3 vs. 2.7 nM) and higher selectivity than U-101,958 at dopamine D4 receptors, over dopamine D2 and D3 receptors in transfected cell membranes and
Compounds selective for dopamine receptor subtypes.
Kebabian, et al.
Drug Discovery Today, 2, 333-340 (1997)
F Henry et al.
Theriogenology, 83(8), 1373-1380 (2015-03-05)
From many endangered or threatened species which are expected to profit from assisted reproduction techniques, mainly epididymal sperm of dead or freshly castrated males are available. These sperm had contact to epididymal secretion products but not to seminal fluid components.

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