推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 17 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates
indirect immunofluorescence: 5-10 μg/mL using paraformaldehye-fixed HeLa cells
western blot: 0.5-1 μg/mL using HEK-293T cell extracts
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... RPL26(6154)
mouse ... Rpl26(19941)
rat ... Rpl26(287417)
一般說明
RPL26 (ribosomal protein L26) is located on chromosome 17. It codes for a 145-amino-acid long protein and has four exons. It is present on the large ribosomal subunit.
Ribosomal protein L26 is one of the large ribosomal subunit proteins.
特異性
Anti-Ribosomal Protein L26 (N-terminal) specificallyrecognizes human Ribosomal Protein L26.
免疫原
synthetic peptide corresponding to amino acids 1-17 of human ribosomal protein L26, conjugated to KLH via a C-terminal added cysteine residue. The sequence is conserved in human, rat, and mouse.
應用
Anti-Ribosomal Protein L26 (N-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunostaining
- immunofluorescence
- coimmunoprecipitation analysis
生化／生理作用
RPL26 (ribosomal protein L26) regulates the expression of p73. It plays an important role in translation and stability of ribosomes. RPL26 frameshift mutation can cause several physical abnormalities.
Ribosomal proteins are implicated in mRNA recognition, tRNA recognition and decoding and nuclear export. It was shown together with nucleolin to bind to the 5′ untranslated region of p53 mRNA and to control p53 translation and induction after DNA damage.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner
Jayaraman S, et al.
Nucleic Acids Research, 45(20), 11725-11742 (2017)
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-beta Peptide Generation In Vivo
Serrano-PA, et al.
Testing, 12(1), e0170345-e0170345 (2017)
p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability
Zhang M, et al.
Oncotarget, 7(48), 78255-78268 (2016)
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
Gazda HT
Human Mutation, 33(7), 1037-1044 (2012)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Ofir-RY, et al.
Molecular Cell, 32(2), 180-189 (2008)
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