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P8861

Sigma-Aldrich

Pyrrolnitrin from Pseudomonas cepacia

≥98% (HPLC), solid

同義詞:

3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole

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About This Item

CAS號碼:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

抗生素活性譜

fungi

作用方式

enzyme | inhibits

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl

InChI

1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H

InChI 密鑰

QJBZDBLBQWFTPZ-UHFFFAOYSA-N

特異性

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

應用

Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.

生化/生理作用

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.
Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Magdalena M Rose et al.
Environmental microbiology, 23(9), 5525-5540 (2021-08-05)
The unicellular alga Chlamydomonas reinhardtii and the bacterium Pseudomonas protegens serve as a model to study the interactions between photosynthetic and heterotrophic microorganisms. P. protegens secretes the cyclic lipopeptide orfamide A that interferes with cytosolic Ca2+ homeostasis in C. reinhardtii
El-Banna, N., and Winkelmann, G.
Applied Microbiology, 85, 69-69 (1998)
Chernin, L., et al.
Current Microbiology, 32, 208-208 (1996)
Natural Antimicrobials for the Minimal Processing of Foods, 201-201 (2003)
Suppression of damping-off of cucumber caused by Pythium ultimum with live cells and extracts of Serratia marcescens N4-5
Roberts DP, et al.
Soil Biology and Biochemistry, 39(9), 2275-2288 (2007)

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