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Merck
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文件

P8419

Sigma-Aldrich

5-n-Propyluracil

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About This Item

經驗公式(希爾表示法):
C7H10N2O2
CAS號碼:
分子量::
154.17
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:

形狀

solid

SMILES 字串

CCCC1=CNC(=O)NC1=O

InChI

1S/C7H10N2O2/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)

InChI 密鑰

JHEKLAXXCHLMNM-UHFFFAOYSA-N

應用

5-n-Propyluracil is used as a reagent for the synthesis of anti-HIV drugs of the 5-propyluracil class.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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A Miazga et al.
Nucleosides, nucleotides & nucleic acids, 29(4-6), 438-444 (2010-06-15)
New homo- and hetero-P(1),P(2)-dinucleotides were prepared with the use of multistep procedures starting from the monophosphates of 3'-fluoro-2-thiothymidine, 3'-fluoro-4-thiothymidine, AZT and 1-[(2-hydroxyethoxy)-methyl-5-propyl-6-phenylselenenyl]uracil. Anti-HIV properties of the synthesized P(1),P(2)-dinucleotides were evaluated against laboratory syncytia inducing strain HIV-1 in CEM-T4 cells. Anti-HIV
Agnieszka Miazga et al.
Acta biochimica Polonica, 54(4), 863-868 (2007-12-11)
Novel 6-phenylselenenyl-5-propyluracils were synthesized from 5-propyluracil with the use of regioselective synthesis to give 1-[(2-hydroxyethoxy)-methyl]-6-phenylselenenyl-5-propyluracil (6), 1-ethoxymethyl-6-phenylselenenyl-5-propyluracil (9) and 1-benzyloxymethyl-6-phenylselenenyl-5-propyluracil (10). Interaction of these compounds with recombinant HIV-1 reverse transcriptase (RT) was evaluated using a non-isotopic colorimetric method. Compounds 9

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