P5624

PD-118057

≥98% (HPLC), solid

• 同義詞: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
• 經驗公式（希爾表示法）: C₂₁H₁₇Cl₂NO₂
• CAS號碼: 313674-97-4
• 分子量：: 386.27
• MDL號碼: MFCD08705328
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724580
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: light yellow
• 溶解度: DMSO: 9 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2
• InChI: 1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
• InChI 密鑰: ZCQOSCDABPVAFB-UHFFFAOYSA-N

描述

生化／生理作用

PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H413
• 防範說明: P273 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves