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Key Documents

P4547

Sigma-Aldrich

Prostaglandin A2 solution

10 mg/mL in methyl acetate, ~95%, synthetic

同義詞:

(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid, PGA2

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About This Item

經驗公式(希爾表示法):
C20H30O4
CAS號碼:
分子量::
334.45
Beilstein:
2221844
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

生物源

synthetic

化驗

~95%

濃度

10 mg/mL in methyl acetate

儲存溫度

−20°C

SMILES 字串

[H][C@]1(\C=C\[C@@H](O)CCCCC)C=CC(=O)[C@]1([H])C\C=C/CCCC(O)=O

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生化/生理作用

Blocks cell cycle at G2/M; induces apoptosis in tumor cells; inhibits viral replication; PPARγ agonist.

象形圖

FlameExclamation mark

訊號詞

Danger

危險聲明

危險分類

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

標靶器官

Central nervous system

安全危害

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

15.8 °F

閃點(°C)

-9 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


分析證明 (COA)

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Takumi Satoh et al.
The European journal of neuroscience, 17(11), 2249-2255 (2003-06-20)
Previously we found that some cyclopenteone prostaglandin derivatives (PGs), referred to as neurite outgrowth-promoting PGs (NEPPs), have dual biological activities of promoting neurite outgrowth and preventing neuronal death [Satoh et al. (2000) J. Neurochem., 75, 1092-1102; Satoh et al. (2001)
Emmanuel Gaquerel et al.
Biochimica et biophysica acta, 1771(5), 565-575 (2007-04-13)
Signaling cascades involving oxygenated derivatives (oxylipins) of polyunsaturated fatty acids (PUFAs) are known to operate in response to external stimuli. The marine red alga Chondrus crispus uses both oxygenated derivatives of C18 (octadecanoids) and C20 (eicosanoids) PUFAs as developmental or
Fabiano E Xavier et al.
Clinical science (London, England : 1979), 119(7), 283-292 (2010-05-13)
Our present study examines, in mesenteric resistance arteries, possible vasodilation alterations, and the role of NO and COX (cyclo-oxygenase) derivatives, in cirrhosis. The vasodilator response to acetylcholine was analysed in segments from control and cirrhotic rats. The effects of the
K Ohno et al.
Chemico-biological interactions, 78(1), 67-75 (1991-01-01)
Prostaglandin A2 (PGA2) stimulates the biosynthesis of gamma-glutamylcysteine synthetase and elevates glutathione (GSH) contents in cultured mammalian cells. To clarify the importance of gamma-glutamylcysteine synthetase induction in the defence of endothelial cells against oxidative stress, the effect of PGA2 on
Patricia Reyes-Martin et al.
Pharmacological research, 57(5), 344-350 (2008-05-06)
15-Deoxy-delta12,14-prostaglandin-J(2) (15d-PGJ(2)) has potent anti-inflammatory effects including the inhibition of interleukin-1beta (IL-1beta)-induced expression of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) production in several cell types. 15d-PGJ(2) contains an alpha,beta-unsaturated electrophilic ketone and several evidences suggest that thiol reducing agents prevent

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